Same effect of sublingual and oral Captopril in hypertensive crisis

ABSTRACT

Evvah Karakılıç, Fatih Büyükcam , Güler Kocalar, Selçuk Gedik, Enver Atalar

BACKGROUND AND OBJECTIVES: Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic eleva- tion of blood pressure (BP) that is commonly seen in Emergency Departments. Oral or sub- lingual captopril is commonly used in the Emer- gency Departments. The unpleasant taste of the sublingual drugs causes uncomfortable condi- tion to the patient. Studies showing no differ- ence between oral and sublingual captopril has been ignored so far. Herein we compared the oral and sublingual captopril efficiency in the hypertensive urgencies.

MATERIALS AND METHODS: In this retro- spective observational study, 71 patients admit- ted with hypertensive urgency to Emergency Departments of two hospitals in 2011 whose blood pressure were recorded before captopril administration and blood pressure were record- ed after captopril administration at 0-5-15-30- 45-60 minutes were included the study. The re- ductions of the blood pressure of oral and sub- lingual captopril groups were compared.

RESULTS: There were 28 patients at oral and 43 at sublingual captopril group. The mean age ± SD was 58.13 ± 8.66 years and 41 (57.7%) pa- tients were female. The most common com- plaints were headache, nausea/vomiting and weakness. 65 (91.5%) patients were using anti- hypertensive drugs before admitted to hospital. The blood pressure at 0, 5, 15, 30, 45 and 60th minutes of therapy didn’t show any difference between oral and sublingual captopril use.

CONCLUSIONS: There was any difference be- tween oral and sublingual captopril efficiency to control of hypertension in patient with hyper- tensive urgency. For a more comfortable treat- ment, oral captopril may be a more convenient choice in the hypertensive urgencies.

Key Words: Captopril, Hypertensive urgency, Hypertensive emergency, Oral, Sublingual

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